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CViSB study shows how Mardi Gras 2020 accelerated Louisiana’s first COVID-19 wave

A CViSB-led study published in Cell outlines how the New Orleans’ Mardi Gras festival of February 2020 appears to have driven one of the worst early outbreaks of COVID-19 in the United States. Investigators sequenced and analyzed the COVID-19-causing coronavirus, SARS-CoV-2, recovered from patients, as well as data on population movements, COVID-19 deaths, and other relevant sources of information for…
Michelle McGraw
July 30, 2021
Publication

Investigation of a rare Ebola relapse case in Central Africa

A CViSB collaboration recently published their findings on an important Ebola relapse case in the Democratic Republic of Congo. A 25-year-old man who had been vaccinated against Ebola in December of 2018 fell ill with the disease six months later. He received experimental treatments for Ebola and was released from the hospital on June 29th, 2019. Unfortunately, the illness returned…
Michelle McGraw
May 6, 2021
Publication

The emergence of SARS-CoV-2 in Europe and North America

Accurate understanding of the global spread of emerging viruses is critically important for public health responses and for anticipating and preventing future outbreaks. In a recent study published in Science, CViSB investigators and colleagues investigate when, where, and how the earliest sustained SARS-CoV-2 transmission networks became established in Europe and North America. The results suggest that rapid early interventions successfully…
Michelle McGraw
September 11, 2020
measles studyPublication

The history of measles

Many infectious diseases are thought to have emerged in humans after the Neolithic revolution. While it is broadly accepted that this also applies to measles, the exact date of emergence for this disease is controversial. In a recent study from CViSB investigators and colleagues, the genome of a 1912 measles virus was sequenced from a formalin-preserved lung, representing the oldest…
Kristian Andersen
January 11, 2020
abstractPublication

Zika surveillance study in Cell

A new CViSB study investigating smoldering 'hidden' outbreaks of Zika in the Americas was published on the cover of Cell. In this paper we used travel surveillance and genomic epidemiology to answer a simple question - "in 2017, was the epidemic over?". The short answer, is no - read the rest of the study for the long answer. The Zika…
Kristian Andersen
August 24, 2019
brineyPublication

Can humans produce a quintillion antibodies?

An analysis by CViSB scientists at Scripps Research of billions of distinct antibody-producing immune cells sampled from human volunteers indicates that the human antibody “repertoire” is far larger than was once thought. The finding, reported online on January 21 in Nature, suggests that humans may be capable of producing as many as 10^18, or one quintillion, distinct antibodies. The study…
Kristian Andersen
January 24, 2019
vic_abstract_cellPublication

Ebola study w. VIC consortium

In two papers published in Cell and Cell Host Microbe CViSB investigators, together with colleagues from our VIC sister consortium, describe in detail antibody responses to Ebola. By systematic analysis of a large set of more than 170 monoclonal antibodies to Ebola virus, the researchers show which immunological features play key roles in protection against the virus. The researchers aimed to…
Kristian Andersen
August 9, 2018
lassa_rdtPublication

Rapid diagnosis of Lassa

A new study from VHFC researchers provide validation for a new rapid diagnostic test for Lassa fever. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a patient’s clinical presentation. In this study, the field performance of recombinant antigen-based Lassa fever immunoassays was compared to that of quantitative polymerase chain…
Kristian Andersen
April 12, 2018