Center for Viral Systems Biology

We are a group of scientists interested in understanding what genetic, immunological, and physiological factors determine the outcome of human disease from viral infections.

Leadership

Kristian Andersen

Kristian Andersen

Director & Principal Investigator

Assistant Professor
The Scripps Research Institute

Bio: Kristian G. Andersen, Ph.D. is an Assistant Professor at the Scripps Research Institute and Director of Infectious Disease Genomics at the Scripps Translational Science Institute. He obtained his Ph.D. in immunology from the University of Cambridge in 2009, where he performed his research at the MRC Laboratory of Molecular Biology. He performed postdoctoral work in Pardis Sabeti's group at Harvard University and the Broad Institute before joining Scripps in 2015.

Over the past decade, his research has focused on the complex relationship between host and pathogen. Using a combination of next-generation sequencing, field work, experimentation and computational biology he has spearheaded large international collaborations investigating the spread and evolution of highly deadly pathogens, including Zika virus, Ebola virus, and Lassa virus.

He has received several awards, including the Max Perutz Prize in 2008, a Carlsberg Foundation Fellowship in 2009, and was chosen as a PEW Biomedical Scholar in 2016.

Role: Dr. Andersen is the PI for the Center and is leading the Admin Core and Project 2. In addition to overseeing all Center activities, he is investigating viral factors influencing the outcome of human infection with Ebola virus and Lassa virus.

bob_garry

Robert Garry

Co-director

Professor
Tulane University

Bio: Robert F. Garry, Ph.D. is Professor of Microbiology and Immunology and Associate Dean for the Graduate Program in BioMedical Sciences at Tulane Medical School. Dr. Garry carried out doctoral studies in Microbiology at the University of Texas at Austin under the direction of Dr. Marilynn R.F. Waite and received his Ph.D. in 1978.

His lab interacts with a consortium of academic, industrial and industry scientists who are developing countermeasures, including diagnostics, immunotherapeutics and vaccines, against Lassa virus, Ebola and Marburg viruses, flaviviruses and other high consequence pathogens. Other efforts include structural and molecular investigations to deepen understanding of the pathogenesis of viral hemorrhagic fevers while providing training for West African scientists and further developing research and clinical trial infrastructure in Sierra Leone and Nigeria.

Role: Dr. Garry, together with Dr. Andersen, is managing the operations of CViSB in his role as Co-Director. He is also leading Project 1, where he is investigating host responses following infection with Ebola virus and Lassa virus. Together with Dr. Schieffelin, he also oversees the clinical operations in Sierra Leone.

andrew_su

Andrew Su

Lead, Data & Bioinformatics Core

Professor
The Scripps Research Institute

Bio: Andrew I. Su, Ph.D. is a Professor at the Scripps Research Institute in the Department of Integrative, Structural and Computational Biology. He received his Ph.D. in Chemistry from Scripps in 2002.

His research focuses on building and applying bioinformatics infrastructure for biomedical discovery. His research has a particular emphasis on leveraging crowdsourcing for genetics and genomics. Representative projects include the Gene Wiki, BioGPS, MyGene.Info, and Mark2Cure, each of which engages “the crowd” to help organize biomedical knowledge. These resources are collectively used millions of times every month by members of the research community, by students, and by the general public.

Role: Dr. Su is leading the Data and Bioinformatics Core where he is coordinating all data collections, analyses, and public releases across CViSB.

marc_suchard

Marc Suchard

Lead, Modeling Core

Professor
University of California, Los Angeles

Bio: Marc A. Suchard, M.D./Ph.D is a Professor at the University of California in Los Angeles (UCLA). He received a bachelor’s degree in biophysics from the University of California, Berkeley in 1995 and spent two years at Oxford University as a British Marshall Scholar. He then earned his Ph.D in biomathematics from the UCLA in 2002 and continued for a M.D. degree, which he received in 2004, also from UCLA.

His research is on the forefront of high-performance statistical computing. He is a leading Bayesian statistician who focuses on inference of stochastic processes in biomedical research and in the clinical application of statistics. His training in both Medicine and Applied Probability help bridge the gap of understanding between statistical theory and clinical practicality.

He has been awarded several prestigious statistical awards such as the 2003 Savage Award, the 2006 Mitchell Prize, as well as a 2007 Alfred P. Sloan Research Fellowship in computational and molecular evolutionary biology and a 2008 Guggenheim Fellowship to further computational statistics. Recently, he received the 2011 Raymond J. Carroll Young Investigator Award for a leading statistician within 10 years post-Ph.D. He is an elected Fellow of the American Statistical Association.

Role: Dr. Suchard is leading the Modeling Core where he is devloping new statistical tools for large-scale data analysis. He is also overseeing all analyses of CViSB.

bryan

Bryan Briney

Lead, Technology Core

Assistant Professor
The Scripps Research Institute

Bio: Bryan Briney, Ph.D. is an Assistant Professor of Immunology and Microbiology at the Scripps Research Institute. He obtained his B.S. in Biochemistry and Cell Biology from the University of California, San Diego and his Ph.D. from Vanderbilt University in 2012. He performed postdoctoral work in Dennis Burton's laboratory at the Scripps Research Institute.

His research is focused on genetic analysis of adaptive immune responses to infection and immunization. Previous work has studied the development of broadly neutralizing antibody responses to Zika, influenza and HIV as well as qualitative analyses of antibody responses to candidate HIV immunogens.

Role: Dr. Briney is leading the Technology Core where he is developing and using high-throughput technologies for CViSB data production. He is also assisting on Project 1, where he is investigating evolutionary pathways of T- and B-cell development in Ebola and Lassa patients.

galit_alter

Galit Alter

Co-Lead, Technology Core

Associate Professor
Ragon Institute & Harvard Medical School

Bio: Galit Alter, Ph.D. is Group Leader at the Ragon Institute of MGH, MIT and Harvard and an Associate Professor at Harvard Medical School. She received her PhD in experimental medicine from McGill University in 2004.

Over the past decade her research has focused on understanding the role of the innate immune response to chronic viral infections, including HIV and HCV, with a focus on defining the role of Natural Killer (NK) cells in antiviral control. Recently, these studies have shifted gears to begin to define the mechanism by which these innate immune effector cells may be harnessed through vaccination to gain more effective control over viral replication. To do this, her current research interests lie in defining the role of innate immune recruiting antibodies in providing protection from infection.

Role: Dr. Alter is assisting Dr. Briney on the Technology Core where she is developing high-throughput serological assays for investigating B-cell mediated immune responses following infection with Ebola virus and Lassa virus. She is also working with Drs. Andersen and Garry on the Projects.

doug_lauffenburger

Douglas Lauffenburger

Co-Lead, Modeling Core

Ford Professor of Bioengineering
Massachusetts Institute of Technology

Bio: Douglas A. Lauffenburger, Ph.D. is Ford Professor of Bioengineering and (founding) Head of the Department of Biological Engineering at the Massachusetts Institute of Technology (MIT). He also with appointments in the Department of Biology and the Department of Chemical Engineering. He received his Ph.D. from Ph.D. from the University of Minnesota in 1979.

His laboratory emphasizes integration of experimental and mathematical/computational analysis approaches, toward development and validation of predictive models for physiologically-relevant behavior in terms of underlying molecular and cellular network properties. His focus has been on fundamental aspects of cell dysregulation, complemented by translational efforts in identifying and testing new therapeutic ideas. Applications addressed have chiefly resided in cancer, inflammatory disease, and the immune system including especially for vaccines.

He has received numerous awards including an NSF Presidential Young Investigator Award in 1984, a Guggenheim Fellowship in 1989, and a Systems Biology Pioneer Award, SPIE in 2011. He is a Biomedical Engineering Society Fellow, and an elected member of the National Academy of Engineering and the American Academy of Arts & Sciences.

Role: Dr. Lauffenburger is assisting Dr. Suchard on the Modeling Core where he is developing new machine learning methods for analyzing longitudinal multivariate datasets, including those produced by CViSB.

john_schieffelin

John Schieffelin

Clinical Director

Assistant Professor
Tulane University

Bio: John S. Schieffelin, M.D. is an infectious disease doctor at Tulane University School of Medicine and an Assistant Professor in the Department of Tropical Medicine. He received his medical degree from Tulane University School of Medicine in 2001 and continued his training in a combined Internal Medicine and Pediatrics Residency at Tulane University from 2001-2005. He then went on to complete a combined fellowship training program in Adult and Pediatric Infectious Diseases at Louisiana State University Health Sciences Center in New Orleans and Tulane University from 2005-2009.

In 2009, he joined the Tulane University School of Medicine faculty in the Departments of Medicine & Pediatrics as an Assistant Professor or Clinical Medicine & Pediatrics. He served as an infectious disease doctor in Ebola treatment units in Sierra Leone during the epidemic in West Africa as part of an appointment from the WHO. His primary clinical interests include infections in viral hemorrhagic fever patients, transplant recipients, and tuberculosis.

Role: Dr. Schieffelin is the Clinical Director of CViSB and is overseeing all the clinical operations of the Center in Sierra Leone.

Research

endemic_zoneWhat are the immunological, genetic, microbial and physiological attributes that play essential roles in determining outcomes from viral infections? The mission of the Center for Viral Systems Biology (CViSB) is to identify such factors and elucidate the molecular and immunological networks that determine outcomes of human disease. We hope that via this research we will be able to provide a deep system-level understanding of the virus and human determinants of clinical outcome to discover predictive markers of disease, and guide future therapies.

We will achieve these goals by applying several ‘omics’ technologies, continuous physiological sensing, and high-throughput experimental approaches to unique patient and survivor cohorts of Lassa fever and Ebola virus disease in West Africa. We will develop predictive models for identifying critical disease correlates and analyze large-scale data sets to pinpoint causal host-pathogen interactions. By elucidation the molecular networks that play critical roles in clinical outcomes, this research will allow us to identify new targets for medicines and vaccines, inform personalized treatment strategies, and provide novel computational algorithms applicable to a wide range of other human pathogens.

News

lassa_rdt
Publication

Rapid diagnosis of Lassa

A new study from VHFC researchers provide validation for a new rapid diagnostic test for Lassa fever. It is difficult to distinguish febrile illnesses that are common in West Africa from Lassa fever based solely on a patient’s clinical presentation. In this study, the field performance of recombinant antigen-based Lassa fever immunoassays was compared to that of quantitative polymerase chain…
hills
Jobs

We’re hiring

We are looking for postdocs, administrators, and staff scientists to join us in our mission to identify the factors determining outcomes of human infectious disease. We are looking for both wet-lab and computational biologists - people interested in 'field work' in Sierra Leone are more than welcome to apply. (more…)
jeeps
Press Release

Press Release

TSRI scientists receive $15 million to study viral outbreak survivors. With a new $15 million grant, scientists at The Scripps Research Institute (TSRI) are gearing up for an in-depth study of survivors of viral outbreaks. (more…)

Partners

vhfc
acegid
niaid
tsri
tulane
ucla
mit
harvard